Ethical clearance and fulfillments of other regulatory affairs
This is to state that the present study was carried out in accordance with the National Institutes of Health, USA guidelines and the institutional ethical concerns, relevant guidelines and regulations were maintained throughout the investigation. This study confirms that all experimental protocols were approved by the institutional (Oriental Institute of Science and Technology) Ethics Committee (oist/EC/hu/bt/16/). This is also to state that informed consent was obtained from all participants who were at their post-menopausal age.
Female Wistar rats were purchased from a small-animal firm house (Govt. registered) that follows all ethical norms and maintain requisite regulatory affairs. The firm house is a Government accredited (CPCSEA-Committee for the Purpose of Control and Supervision of Experiments on Animals: Reg. no 1A2A/PO/BT/S/15/CPCSEA. organization under the Dept of Animal Husbandry and Dairy, Ministry of Agriculture and Farmer’s Welfare, Govt. of India. Proper permissions for all animal experiments, were obtained from the Institutional (Oriental Institute of Science and Technology) Review Board.