CONCLUSIONS
The current study explores the events of the redox dependent adverse regulations of SULT1E1 and possible foul-play of estradiol in breast cancer tissues of postmenopausal women. This has been linked to the induction of HIF1α and MMP2/9 activation. In an attempt towards the therapeutic approach, we have demonstrated that dially sulfide is a good inducer of SULT1E1 gene and protein which significantly decreased the HIF1α and MMPs. In addition chalcone played an ideal rectifier role of cellular redox environment. Together, the two drugs may be applied as effective therapeutic materials against some forms of breast cancer. To make definitive statements, proper pharmacological testing must be performed.
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