CONCLUSIONS
The current study explores the events of the redox dependent adverse
regulations of SULT1E1 and possible foul-play of estradiol in breast
cancer tissues of postmenopausal women. This has been linked to the
induction of HIF1α and MMP2/9 activation. In an attempt towards the
therapeutic approach, we have demonstrated that dially sulfide is a good
inducer of SULT1E1 gene and protein which significantly decreased the
HIF1α and MMPs. In addition chalcone played an ideal rectifier role of
cellular redox environment. Together, the two drugs may be applied as
effective therapeutic materials against some forms of breast cancer. To
make definitive statements, proper pharmacological testing must be
performed.
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