2.1 Data source
OpenVigil 2.1 (https://openvigil.sourceforge.net/) is an online tool
used for data mining and pharmacovigilance data analysis, which has been
widely utilized in pharmacovigilance research.[15] In this study, we
employed this online tool to retrieve data from the FAERS database. The
search period was set from January 1, 2013, to January 1, 2023 for
pirfenidone and January 1, 2014, to January 1, 2023 for nintedanib
according to their respective launch dates. Various pharmaproduct names
of pirfenidone (such as ’esbriet’, ’pirfenidone aet’, ’pirfenidone
axunio’, ’pirfenidone viatris’, ’truemed group llc’) and ’ofev’ or
’vargatef’ for nintedanib were used as search terms. Only primary
suspect roles were considered for the analysis.