Ulich TR et al.3
|
15 male Sprague Dawley rats given
cyclophosphamide |
not applicable |
5 mg/kg given once 24 hours prior to
cyclophosphamide. |
12 of 15 (80%) of the rats did not have ulcerations
of the bladder epithelium. |
Czibere A et al.4
|
24-year-old male with refractory
T-acute lymphoblastic leukemia given conditioning with fludarabine,
high-dose cytarabine, amsacrine, and total body irradiation prior to
stem cell transplant |
permanent bladder irrigation, cidofovir,
intravenous immune-globulins, oral estrogens |
60 mcg/kg given three
days a week for 15 total doses. Intravesical Uropol S was also given at
this time. |
Bleeding stopped after 12 doses. Hematuria reappeared a few
days later, but resolved after 1 additional week of
treatment. |
Bhaskaran S et al.5
|
12-year-old female with relapse
acute myeloid leukemia given conditioning with busulfan,
cyclophosphamide, and rabbit antithymocyte globulin prior to stem cell
transplant |
bladder irrigation, intra-vesicular cidofovir,
intra-vesicular prostaglandin E2, cidofovir, hyperbaric oxygen |
60
mcg/kg given three days a week for 4 weeks. Hyperbaric oxygen was
continued. |
Complete resolution of gross hematuria 2 weeks after
initiation of palifermin. |