3.4 Cox proportional hazards models
Table 2 shows the results of the Cox proportional hazards models
examining the risk of all-cause mortality in the PAH patients reported
in the JADER database. According to the results of the univariate and
the Kaplan-Meier analyses, we selected 12 variables (sex, age,
epoprostenol, sildenafil, tadalafil, bosentan, ambrisentan, macitentan,
oxygen, warfarin, DOAC, and tolvaptan) for the multivariate analysis
(Model 1). The significant variables in Model 1 and the interaction
between epoprostenol and warfarin were adjusted in Model 2 as a final
model. The HRs of all variables in the univariate analyses were
demonstrated in Supplementary Table S2.