Variable Variable n (%) Model 1a Model 2b
Crude HR (95%CI) Adjusted HR (95%CI) Adjusted HR (95%CI)
Sex Female 833 (69.0) ref. ref. ref.
Male
375 (31.0)
1.38 (1.07–1.77) 1.45 (1.13–1.88) 1.44 (1.11–1.86)
Age <60 581 (48.1) ref. ref. ref.
≥60
627 (51.9)
2.34 (1.81–3.03) 2.19 (1.66–2.88) 2.17 (1.65–2.85)
Epoprostenol Non-user 1009 (83.5) ref. ref. ref.
User
199 (16.5)
0.47 (0.32–0.69) 0.58 (0.38–0.88) 0.38 (0.23–0.64)
Sildenafil Non-user 930 (77.0) ref. ref. ref.
User
278 (23.0)
1.48 (1.15–1.92) 1.60 (1.16–2.20) 1.56 (1.19–2.04)
Tadalafil Non-user 696 (57.6) ref. ref. -
User
512 (42.4)
0.76 (0.60–0.98) 1.04 (0.77–1.40)
-
Bosentan Non-user 984 (81.5) ref. ref. ref.
User
224 (18.5)
0.75 (0.55–1.04) 0.41 (0.28–0.61) 0.42 (0.28–0.61)
Ambrisentan Non-user 977 (80.9) ref. ref. ref.
User
231 (19.1)
1.41 (1.05–1.88) 0.65 (0.45–0.94) 0.67 (0.47–0.96)
Macitentan Non-user 670 (55.5) ref. ref. ref.
User
538 (44.5)
0.61 (0.48–0.79) 0.32 (0.22–0.45) 0.30 (0.22–0.42)
Oxygen Non-user 981 (81.2) ref. ref. -
User
227 (18.8)
0.61 (0.44–0.85) 0.80 (0.55–1.16)
-
Warfarin Non-user 916 (75.8) ref. ref. ref.
User
292 (24.2)
0.87 (0.65–1.16) 0.74 (0.55–0.99) 0.62 (0.45–0.86)
DOAC Non-user 1154 (95.5) ref. ref. -
User
54 (4.5)
1.51 (0.93–2.44) 0.93 (0.56–1.54)
-
Tolvaptan Non-user 1044 (86.4) ref. ref. ref.
User
164 (13.6)
1.75 (1.29–2.37) 2.02 (1.46–2.80) 1.99 (1.46–2.71)
Epoprostenol:Warfarin (Interaction term) Epoprostenol:Warfarin (Interaction term)
-
-
-
3.94 (1.75–8.86)
aAll selected variables were adjusted in Model 1. bThe significant variables in Model 1 and the interaction term were adjusted in Model 2. HR, hazard ratio; CI, confidence interval; ref., reference; DOAC, direct oral anticoagulant aAll selected variables were adjusted in Model 1. bThe significant variables in Model 1 and the interaction term were adjusted in Model 2. HR, hazard ratio; CI, confidence interval; ref., reference; DOAC, direct oral anticoagulant aAll selected variables were adjusted in Model 1. bThe significant variables in Model 1 and the interaction term were adjusted in Model 2. HR, hazard ratio; CI, confidence interval; ref., reference; DOAC, direct oral anticoagulant aAll selected variables were adjusted in Model 1. bThe significant variables in Model 1 and the interaction term were adjusted in Model 2. HR, hazard ratio; CI, confidence interval; ref., reference; DOAC, direct oral anticoagulant aAll selected variables were adjusted in Model 1. bThe significant variables in Model 1 and the interaction term were adjusted in Model 2. HR, hazard ratio; CI, confidence interval; ref., reference; DOAC, direct oral anticoagulant aAll selected variables were adjusted in Model 1. bThe significant variables in Model 1 and the interaction term were adjusted in Model 2. HR, hazard ratio; CI, confidence interval; ref., reference; DOAC, direct oral anticoagulant