5.1 - Annexin A1 (AnxA1)
Annexin A1 (AnxA1) is a protein consisting of 346 amino acids that is synthesized by various cell types including macrophages, neutrophils, lung fibroblasts, and epithelial cells. AnxA1 expression is increased upon administration of glucocorticoids. It was initially discovered as an inhibitor of Phospholipase A2. Several pre-clinical studies have provided evidence for both the endogenous pro-resolving role and the therapeutic potential of AnxA1 (Flower et al., 1979; Ernst et al., 1990; Hannon et al., 2002).