Figure legends:
Figure 1: The double-edge role of inflammation in the context of infection. (1) Pathogens (viruses or bacteria) infect host-cells. Inflammation is needed for pathogen control. (2) Mediators of inflammation recruit and activate leukocytes and resident cells, (3) events that are associated with local containment of infection and induction of protective immune response. (4) When inadequate, the inflammatory response may cause (5) disease. Here, we discuss how mediators pro-resolving therapies contribute to the control of disease during infection.
Figure 2: Therapeutic effects of Ang-(1-7) against infectious diseases . Ang-(1-7) exerts its effects by binding to MasR receptors, leading to the amelioration of inflammation and disease signs. This has been observed in various models of respiratory infection. In both (A) viral (e.g., H1N1) and (B) bacterial (e.g. Staphylococcus aureus) infections, Ang-(1-7) induced pro-resolving effects and decreased viral and bacterial loads. It has been shown to induce pro-resolving effects, meaning it helps resolve the inflammatory response and promotes tissue repair.