7.2 - GILZ and viral infections
To date, no studies have demonstrated the pro-resolutive effect of GILZ during viral infections. In fact, research has shown that GILZ binds to STAT1 and hinders its translocation to the nucleus, thereby reducing the expression of type I interferon-induced genes (Nataraja et al., 2022). This suggests that GILZ may have a detrimental impact on the host during certain viral infections. Additionally, studies have revealed that the infectious bursal disease virus (IBDV) thwarts the ubiquitination and degradation of GILZ in the cytoplasm through the viral protein VP4, leading to the inhibition of type I interferon production in vitro . Knockdown of GILZ using siRNA significantly impeded IBDV replication (He et al., 2018; Li et al., 2013). Further investigations are required to establish the precise role of GILZ during viral infections.