Figure legends:
Figure 1: The double-edge role of inflammation in the context of
infection. (1) Pathogens (viruses or bacteria) infect host-cells.
Inflammation is needed for pathogen control. (2) Mediators of
inflammation recruit and activate leukocytes and resident cells, (3)
events that are associated with local containment of infection and
induction of protective immune response. (4) When inadequate, the
inflammatory response may cause (5) disease. Here, we discuss how
mediators pro-resolving therapies contribute to the control of disease
during infection.
Figure 2: Therapeutic effects of Ang-(1-7) against
infectious diseases . Ang-(1-7) exerts its effects by binding to MasR
receptors, leading to the amelioration of inflammation and disease
signs. This has been observed in various models of respiratory
infection. In both (A) viral (e.g., H1N1) and (B) bacterial (e.g.
Staphylococcus aureus) infections, Ang-(1-7) induced pro-resolving
effects and decreased viral and bacterial loads. It has been shown to
induce pro-resolving effects, meaning it helps resolve the inflammatory
response and promotes tissue repair.