Methods
We searched MEDLINE, EMBASE and Cochrane for studies published in
English that focused on clinical drug trials in older people, using
keywords “frailty”, “frail elderly”, “frail”, “pharmacology”,
“clinical pharmacology”, “drug trial”. Abstracts were screened and
any duplicates removed. We included randomised controlled drug trials
that included older people and had included subgroup analyses by
frailty.