3.3 Relationship between air pollutant exposure in early life
and the risk of childhood eczema
Pollutant concentrations were divided according to quartiles and binary
logistic regression analysis was performed (Table 4). In the single
pollutant model, the results showed that increased O3concentrations during pregnancy were a risk factor for cumulative eczema
[1.12(1.06-1.19)], one-year-old eczema [1.10(1.04-1.17)], and
two-year-old eczema [1.15(1.02-1.29)]. In the multi-pollutant model,
PM2.5, PM2.5-10 and PM10with VIF values >5 were considered to have
multicollinearity and were not included in the model at the same time,
and after adjusting for other pollutants and six variables that were
statistically significant in the univariate analysis: parental allergy,
work during pregnancy, monthly household income, maternal primipara,
frequent window opening and air purifier use, PM10exposure during pregnancy had a significant effect on
cumulative eczema
[1.27(1.14-1.41)], 1-year old eczema [1.22(1.09-1.36)], and
2-year-old eczema [1.30(1.04-1.62)]. Dividing PM10into PM2.5 and PM2.5-10,
PM2.5-10 remained positively associated with the risk of
cumulative eczema [1.31(1.20-1.43)], 1-year old eczema
[1.31(1.19-1.44)], and 2-year-old eczema [1.20(1.01-1.44)],
while PM2.5 had no significant effect.
Table 4 OR and 95% CI of air pollutant exposure during
pregnancy for eczema risk in the binary logistic regression model.