Intervention with hydralazine during established hypertension
reduces blood pressure but not brain inflammation or cognitive
impairment
Angiotensin II infusion increased systolic blood pressure which was
sustained for 28 days (Figure 8A). In some mice, intervention with
hydralazine from day 14 to 28 of angiotensin II infusion reduced blood
pressure to almost baseline (Figure 8A). However, at day 28 there was no
significant difference between groups in either immune cell numbers in
the brain (Figure 8C) or cognitive function (Figure 8E).