Intervention with hydralazine during established hypertension reduces blood pressure but not brain inflammation or cognitive impairment
Angiotensin II infusion increased systolic blood pressure which was sustained for 28 days (Figure 8A). In some mice, intervention with hydralazine from day 14 to 28 of angiotensin II infusion reduced blood pressure to almost baseline (Figure 8A). However, at day 28 there was no significant difference between groups in either immune cell numbers in the brain (Figure 8C) or cognitive function (Figure 8E).