Conclusion
Conventionally, Nimesulide and Furosemide are two different groups of drugs but an intense literature search revealed that both drugs have a common sulfonamide functional group which triggered the subsequent episode of TEN. Thus, it is important to note that any patient who has had a previous hypersensitivity reaction to a drug is at high risk for recurrence with another drug having a similar chemical structure, and treating physicians should always consider cross-reactivity between the chosen drugs in order to prevent the subsequent life-threatening clinical episodes.