STUDY SELECTION
All case reports, cohort studies and randomised control trials were included and screened to assess eligibility for inclusion.
A study was eligible for inclusion if it met the following criteria: (1) patients were treated with levetiracetam (regardless of its formulation); (2) patients were undergoing CRRT via continuous veno-venous haemofiltration (CVVHF), continuous veno-venous haemodialysis (CVVHD) or continuous veno-venous haemodiafiltration (CVVHDF). Studies were excluded for the following reasons: (1) it was published in a non-English language; (2) the study was a computational or model-based study not using human patient data; (3) there were insufficient pharmacokinetic data; (4) review article with no additional new pharmacokinetic data.