APPENDICES
APPENDIX 1: SEARCH CRITERIA
Database: Embase <1996 to 2022 Week 02>
Search Strategy:
——————————————————————————–
1 (levetiracetam or keppra).mp. [mp=title, abstract, heading word,
drug trade name, original title, device manufacturer, drug manufacturer,
device trade name, keyword heading word, floating subheading word,
candidate term word] (16748)
2 exp levetiracetam/ (11013)
3 1 or 2 (16748)
4 h#emodialysis.mp. [mp=title, abstract, heading word, drug trade
name, original title, device manufacturer, drug manufacturer, device
trade name, keyword heading word, floating subheading word, candidate
term word] (17934)
5 h#emofiltration.mp. [mp=title, abstract, heading word, drug trade
name, original title, device manufacturer, drug manufacturer, device
trade name, keyword heading word, floating subheading word, candidate
term word] (1190)
6 (continuous renal replacement or continuous renal replacement therapy
or CRRT*).mp. [mp=title, abstract, heading word, drug trade name,
original title, device manufacturer, drug manufacturer, device trade
name, keyword heading word, floating subheading word, candidate term
word] (9078)
7 (CVVH* or continuous veno#venous h#emofil*).mp. [mp=title,
abstract, heading word, drug trade name, original title, device
manufacturer, drug manufacturer, device trade name, keyword heading
word, floating subheading word, candidate term word] (2716)
8 exp hemofiltration/ (8133)
9 exp continuous hemofiltration/ (2655)
10 4 or 5 or 6 or 7 or 8 or 9 (34213)
11 dos*.mp. [mp=title, abstract, heading word, drug trade name,
original title, device manufacturer, drug manufacturer, device trade
name, keyword heading word, floating subheading word, candidate term
word] (2382020)
12 exp drug monitoring/ (40652)
13 (drug monitor* or TDM).mp. [mp=title, abstract, heading word, drug
trade name, original title, device manufacturer, drug manufacturer,
device trade name, keyword heading word, floating subheading word,
candidate term word] (47632)
14 (pharmaco* or PK or PKPD).mp. [mp=title, abstract, heading word,
drug trade name, original title, device manufacturer, drug manufacturer,
device trade name, keyword heading word, floating subheading word,
candidate term word] (2643449)
15 exp pharmacokinetics/ (573589)
16 11 or 12 or 13 or 14 or 15 (4417124)
17 3 and 10 and 16 (58)
18 limit 17 to (english language and yr=”2000 -Current”) (58)
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Database: Ovid MEDLINE(R) ALL <1946 to January 26,
2022>
Search Strategy:
——————————————————————————–
1 (levetiracetam or keppra).mp. [mp=title, abstract, original title,
name of substance word, subject heading word, floating sub-heading word,
keyword heading word, organism supplementary concept word, protocol
supplementary concept word, rare disease supplementary concept word,
unique identifier, synonyms] (4712)
2 exp Levetiracetam/ (2478)
3 exp Renal Dialysis/ (120351)
4 (h#emodialysis or h#emofiltration).mp. [mp=title, abstract,
original title, name of substance word, subject heading word, floating
sub-heading word, keyword heading word, organism supplementary concept
word, protocol supplementary concept word, rare disease supplementary
concept word, unique identifier, synonyms] (16684)
5 (continuous renal replacement or continuous renal replacement therapy
or CRRT*).mp. [mp=title, abstract, original title, name of substance
word, subject heading word, floating sub-heading word, keyword heading
word, organism supplementary concept word, protocol supplementary
concept word, rare disease supplementary concept word, unique
identifier, synonyms] (3737)
6 (CVVH* or continuous veno#venous h#emofil*).mp. [mp=title,
abstract, original title, name of substance word, subject heading word,
floating sub-heading word, keyword heading word, organism supplementary
concept word, protocol supplementary concept word, rare disease
supplementary concept word, unique identifier, synonyms] (1306)
7 exp Hemofiltration/ (7015)
8 exp Continuous Renal Replacement Therapy/ (460)
9 dos*.mp. (2974912)
10 (drug monitor* or TDM).mp. [mp=title, abstract, original title,
name of substance word, subject heading word, floating sub-heading word,
keyword heading word, organism supplementary concept word, protocol
supplementary concept word, rare disease supplementary concept word,
unique identifier, synonyms] (31552)
11 (pharmaco* or PK or PKPD).mp. [mp=title, abstract, original title,
name of substance word, subject heading word, floating sub-heading word,
keyword heading word, organism supplementary concept word, protocol
supplementary concept word, rare disease supplementary concept word,
unique identifier, synonyms] (3875851)
12 exp Pharmacokinetics/ (327036)
13 1 or 2 (4712)
14 3 or 4 or 5 or 6 or 7 or 8 (130778)
15 9 or 10 or 11 or 12 (5989859)
16 13 and 14 and 15 (21)
17 limit 16 to (english language and yr=”2000 -Current”) (20)
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APPENDIX 2: Detailed framework of our hybrid Quality Assessment
Method.