RESULTS
Our search found a total of 58 articles (Fig. 1) . Of 54 articles reviewed in full text, seven fulfilled our eligibility criteria for inclusion. Of the included studies, five were case reports[25,33-36] and two were prospective pharmacokinetic studies[37-38] . In all studies except one (where clinical indication was not recorded) patients were treated with levetiracetam either for known seizures or as prophylaxis (e.g. following traumatic brain injury). In one study [37] four patients were treated with SLED and so were excluded from our data extraction.