CONCLUSION
Levetiracetam clearance in haemofiltration is similar to healthy adults with normal renal function. The current recommendation to dose as in CKD Stage 3b is likely to result in sub-therapeutic drug concentrations in a high number of patients. A twice daily dosing of 500 – 1,000 mg with an initial loading dose of 60mg/kg should be considered in such patients alongside therapeutic drug monitoring.