STUDY SELECTION
All case reports, cohort studies and randomised control trials were
included and screened to assess eligibility for inclusion.
A study was eligible for inclusion if it met the following criteria: (1)
patients were treated with levetiracetam (regardless of its
formulation); (2) patients were undergoing CRRT via continuous
veno-venous haemofiltration (CVVHF), continuous veno-venous
haemodialysis (CVVHD) or continuous veno-venous haemodiafiltration
(CVVHDF). Studies were excluded for the following reasons: (1) it was
published in a non-English language; (2) the study was a computational
or model-based study not using human patient data; (3) there were
insufficient pharmacokinetic data; (4) review article with no additional
new pharmacokinetic data.