PHARMACOKINETIC DATA
Reported levetiracetam clearance from CRRT was between 1.80 – 2.98 L/h
(Table 2 ). Where total clearance was calculated, the clearance
attributed to CRRT alone was between 52 – 73% (Mean 54.7%, S.D.
13.5). Reported total clearance of levetiracetam was between 3.49 –
4.63L/hr (Mean 3.55, S.D. 0.52). Elimination half-life varied
significantly with a range of 5.66 – 12.88 hours and a mean 9.41 hours
(S.D. 2.86, S.E. 0.60). Volume of distribution ranged from 0.45 – 0.73
L/kg. In the majority of patients, peak and trough plasma concentrations
were within the therapeutic target range of 12 – 46 mcg/mL. The
exception to this was in Kalaria et al.’s study in which six patients
demonstrated trough plasma concentrations below 12 mcg/mL (1.93 – 9.94
mcg/mL).