RESULTS
Total clearance was 3.49 – 4.63L/hr (mean 3.55, S.D. 0.52). Elimination
half-life was 5.66 – 12.88 hours (mean 9.41, S.D. 2.86). Volume of
distribution was 0.45 – 0.73 L/kg. Levetiracetam clearance from CRRT
was 52 – 73% (mean 54.7%, S.D. 13.5). At 72 hours, a significant
proportion of simulated patients who received the recommended dose of
levetiracetam demonstrated sub-therapeutic drug concentrations.
Conversely, the majority who received a standard loading dose (60mg/kg)
and twice daily doses in excess of 750mg demonstrated more consistent
therapeutic drug concentrations.