Submission Title A systematic review of the effect of continuous renal replacement therapy on levetiracetam pharmacokinetics in critically ill patients. Do recommended doses achieve therapeutic drug concentrations?
Lead Authors
Dr James Sweatman (Royal Free London NHS Foundation Trust) Ms Sarraa Al-Mahdi (London North West University Healthcare NHS Trust)
Second Authors Dr Dagan O Lonsdale (St. George’s University London, St. George’s University Hospitals NHS Foundation Trust)
Third Authors
Dr Susannah Leaver (St. George’s University Hospitals NHS Foundation Trust) Professor Andrew Rhodes (St. George’s University Hospitals NHS Foundation Trust)
Corresponding Author
Dr Dagan O Lonsdale dlonsdal@sgul.ac.uk
Author Contribution Statement
J.S. and S.A-M. developed the protocol for the presented research. J.S., S.A-M. and D.L. participated in data collection and analysis. D.L. performed the simulated modelling. S.L. and A.R. verified the analytical methods. All authors discussed the results and contributed to the final manuscript.
Keywords Levetiracetam, Keppra, continuous renal replacement therapy, renal replacement therapy, haemodialysis, haemofiltration, pharmacokinetics, PKPD, PK.
Word Count
ABSTRACT 240 words MAIN TEXT 3,212 words
Table Count 4
Figure Count 5
Ethics & Integrity Statement
Funding was received from the St. George’s Hospital Charity and had no impact on the authors’ independence or execution of the research. The authors declare no conflicts of interest in this work. No ethics or patient consent approval were required for this review article. Our protocol was registered on PROSPERO (CRD42022300754) prior to the commencement of the research. No materials within this paper were reproduced from other works. All figures and diagrams are original to this paper.
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.