Figure 3. C-176 significantly improves left forelimb gait deficits 24h post-TBI.
Quantitative temporal gait parameters of mice were measured using DigiGait™ imaging and analysis software 24h after 1.5mm impact CCI surgery (TBI) and no impact (sham). No change in (A) swing duration was observed. Significant improvements found in (B)stance (p<0.0001) and (C) stride duration (p=0.0032),(D) stride frequency (p=0.0011), (E) forelimb stance width (p=0.0254) and (F) gait symmetry (p=0.0237) in TBI mice treated with STING inhibitor (C-176) compared to TBI mice treated with a vehicle. Sham n = 8, TBI-vehicle n = 10, TBI-C-176 n = 13. Data is presented as mean ± SEM. Significance determined by one-way ANOVA with Tukey’s multiple comparison test. *P< 0.05, **P<0.01, ***P<0.001, ****P<0.0001.