Figure 7. Gene expression of pro-inflammatory markers 2h and 24h following TBI and C-176 administration in mice.
Gene expression of pro-inflammatory markers IL-1β (A) ,TNF-⍺ (B), CXCL10 (C), IL-6(D), iNOS (E) and TGF-β (F)measured by qPCR in the ipsilateral cortex or striatal region of the brain 2h and 24h post controlled-cortical impact modelled TBI. All data is presented as mean ± SEM. 2h-TBI n = 6, 24h-TBI n = 9. Significance was determined for the cortex and striatum separately using a one-way ANOVA and Tukey’s multiple comparison test. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p < 0.0001.