Conclusion and Implications:
This study demonstrates the neuroprotective activity of C-176 in
ameliorating acute neuroinflammation and preventing white matter
neurodegeneration post-TBI. This study highlights the therapeutic
potential of small-molecule inhibitors targeting STING for the treatment
of trauma induced inflammation and neuroprotective potential.
Keywords: traumatic brain injury, STING, neuroinflammation,
type-I interferon, neurodegeneration