Key Messages
Children with wheeze/asthma display frequent occurrences and high levels
of sensitization, but c-sIgE sensitization patterns do not clearly
discriminate between non-severe and severe recurrent wheeze / asthma.
Sensitization to non-specific lipid transfer protein (nsLTP) components
was more frequent among SA than NSA, and was associated with lung
function impairment. Cluster analysis of the results for sensitized
children identified seven clusters, of which the two largest were
characterized by “few sensitizations, mainly to house dust mite
(HDM)”. Only one small cluster consisting of “multiple sensitizations,
including to nsLTP”, was associated with severe asthma at school-age.