4. The longitudinal follow-up of the cohort will allow the
comparison of sensitization patterns as biomarkers of disease
trajectories
As expected, we observed an increase in sensitization in terms of the
number of positive c-sIgE and levels of sensitization between the age of
3 and 12 years. Early and multiple sensitizations, in particular to the
airborne allergens HDM and grass pollen, are risk factors for the
persistence of asthma, recurrence, severity of attacks and long-term
lung function impairment (5–9). We did not observe any relationship
between mold sensitization and SRW / SA. This is in contrast with other
studies showing an association between mold exposure, mold sensitization
and asthma exacerbations and/or severe asthma (26–28). However, Mold
sensitization was retained in only a limited number of children in our
study, 9 preschoolers and 15 school-age children, which did not allow
full exploration of its association with severity because of lack of
power. The follow-up of this cohort will make it possible to analyze
sensitization trajectories and provide new insights into the natural
course of sensitization. The pathophysiological mechanisms linking
sensitization patterns to persistent and/or severe asthma, with altered
lung function, may include an unbalanced immune reaction biased toward a
response involving type 2 helper T cells (Th2) in children with early
and multiple occurrences of sensitization (9,29) and exacerbated
interferon production in response to viral infections in children with
late-onset sensitization and asthma (29).