Conclusion
Our case report involves the conversion of a metastatic non-functional
NET into a functional malignant insulinoma. The key clinical points from
this case report are as follows: 1) When a non-functional neuroendocrine
tumor converts into a functional one, the prognosis worsens
significantly. 2) Alternative treatments beyond conventional
chemotherapy are required for patients with aggressive insulinomas. 3)
More research is required to evaluate treatments such as Everolimus and
Sunitinib for their use in cases of malignant insulinomas.