Fig. 11 Schematics of the antiviral mechanism of action of hesperetin against poxviruses
BPXV activates ERK/MNK1/eIF4E signalling. Activated eIF4E binds with the 5’ cap of viral mRNA to initiate translation of the viral proteins. Hesperetin competitively blocks binding of eIF4E with the 5’ cap of viral mRNA, thereby blocking translation of the viral proteins.