Affiliations
1Department
of Microbiology & Infectious Disease Center, School of Basic Medical
Sciences, Peking University, Beijing,
100191, China.
2Department of Cell Biology, School of Basic Medical Sciences, Peking
University, Beijing, 100191, China.
3 National Heart and Lung Institute Faculty of
Medicine (NHLI), Imperial College
22 London, Hammersmith campus, W12 0NN, London, UK
4 Medical Research Institute, Guangdong Provincial
People’s Hospital (Guangdong Academy of Medical Sciences), Southern
Medical University, Guangzhou, 510080, China.
5 Liver Transplantation Center, National Clinical
Research Center for Digestive Diseases, Beijing Friendship Hospital,
Capital Medical University, Beijing 100050, China.
6 Clinical Research Center for Pediatric Liver
Transplantation of Capital Medical University, Beijing 100050, China.
7 Beijing Key Laboratory of Hepatitis C and
Immunotherapy for Liver Diseases, Peking University Hepatology
Institute, Peking University People’s Hospital, Beijing, 100044, China.
# These authors contributed equally to this study
* Corresponding author:
Xiangmei Chen:
Department of Microbiology & Infectious Disease Center, School of Basic
Medical Sciences, Peking University, Beijing, 100191, China.
Tel: +86-10-82802807; Fax: +86-10-82805136;
Fengmin Lu:
Department of Microbiology & Infectious Disease Center, School of Basic
Medical Sciences, Peking University, Beijing,
100191, China.
Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver
Diseases, Peking University Hepatology Institute, Peking University
People’s Hospital, Beijing, 100044, China.
Tel: 86-10-8280-5136; Fax: 86-10-8280-5136
Guiwen Guan
Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Tel: 86-188-1017-2170
Keywords: Hepatitis B virus; Viral integration; PLC/PRF/5;
Multi-omics; Cripsr-cas9; RNA Interference.