Background
Scleroderma(SSc) is a rare connective tissue disorder of unknown etiology characterized by thickness of the skin. The disease usually affects patients between the ages of 30–50  (1). Scleroderma is reported to be associated with Sjogren syndrome, rheumatoid arthritis and systemic lupus erythematosus. It is also associated with solid tumors such as lung, breast, stomach and rectum .however, the association with multiple myeloma (MM) has seldomly been reported (2). To the best of our knowledge, only 14 cases of sceleroderma associated with MM have been reported in the literature. Inflammation and deregulation of immune system in this autoimmune disorder may cause clonal expansions of plasma cells but such aberrations still remain under investigation(2,3).
We report a case of a 58-year-old woman who presented with Systemic sclerosis associated with multiple myeloma.