Figure 2: Timeline of disease management and response to treatment.
A) Overview of the disease status over time. B) Graph showing disease characteristics over time. Monosomy 7 was measured by FISH. CD34 donor chimerism for donor 1 and donor 2 were measured by next generation sequencing at the American Red Cross. Multi-parameter flow cytometry performed at Boston Children’s Hospital was used to measure aberrant blast percentage. AML MRD flow cytometry represents testing done at Hematologics, Inc., Seattle, WA. Lower panel zoomed to improve MRD visualization. C) Overview of treatment over time, inpatient time is highlighted. Immunosuppressive therapy (IST), Donor Lymphocyte infusions (DLI), Fludarabine, Cytarabine and Granulocyte colony-stimulating factor (FLAG).