Figure 1: Myelodysplastic syndrome with excessive blasts.
A) Histology of bone marrow biopsy core (H&E) showing dysplastic megakaryocytes and 10-15% aberrant blasts. B) Bone marrow aspirate (Wright-Giemsa) with dysplastic micro-megakaryocytes, erythroid with nuclear irregularities, and hypo-granular myeloids. C) Karyotype from the time of initial diagnosis, with monosomy 7 detected in 61% cells by FISH. D) Flow cytometry detected 13% myeloid blasts expressing CD13, CD33, CD34, CD117, CD11b, MPO and HLA-DR.