Figure 2: Timeline of disease management and response to
treatment.
A) Overview of the disease status over time. B) Graph showing disease
characteristics over time. Monosomy 7 was measured by FISH. CD34 donor
chimerism for donor 1 and donor 2 were measured by next generation
sequencing at the American Red Cross. Multi-parameter flow cytometry
performed at Boston Children’s Hospital was used to measure aberrant
blast percentage. AML MRD flow cytometry represents testing done at
Hematologics, Inc., Seattle, WA. Lower panel zoomed to improve MRD
visualization. C) Overview of treatment over time, inpatient time is
highlighted. Immunosuppressive therapy (IST), Donor Lymphocyte infusions
(DLI), Fludarabine, Cytarabine and Granulocyte colony-stimulating factor
(FLAG).