Variables Combination group (n=15) Control group (n=43) p value (OR)
Age, years, mean±SD 63.3±9 65.7±15 0.6
Gender, male, n (%) 11 (73.3) 31 (72.1) 0.9
Duration of hospitalization (days), median (IQR) 19 (11) 15 (14) 0.02
Admission to ICU interval (days), median (IQR) 14.5 (22) 6 (7) <0.001
Comorbidities, n (%)
Diabetes mellitus 6 (40) 8/41 (19.5) 0.2
Hypertension 7 (46.7) 19/40 (47.5) 1
Coronary heart disease 3 (20) 6/40 (15) 0.7
Heart failure 1 (6.7) 4/40 (10) 0.7
Chronic renal failure 3 (20) 9 (21) 1
Chronic obstructive pulmonary disease 3 (20) 9/41 (22) 0.9
Malignancy 1 (6.7) 6/42 (14.3) 0.7
Rheumatic disease 2 (13.3) 3/40 (7.5) 0.6
Immunosuppressive drug usage 3 (20) 6 (14) 0.7
cHIS Score, mean±SD 4±1 4±0.9 0.9
Laboratory results, median (IQR)
NLR 6.7 (9.2) 9 (10) 0.5
CRP (mg/L)
Admission 161 (153) 146 (141) 0.6
Max 163 (173) 173 (138) 0.8
Last 30 (218) 67 (153) 0.7
Ferritin (pg/mL)
Admission 334 (588) 492 (575) 0.4
Max 727 (1410) 1032 (1961) 0.3
Last 554 (1528) 531 (1449) 0.7
D-dimer (pg/mL)
Admission 0.89 (0.65) 1.4 (1.1) 0.006
Max 23 (17) 12.3 (20) 0.2
Last 8.4 (14) 5 (16.7) 0.9
LDH (U/L)
Admission 348 (328) 447 (274) 0.5
Max 676 (376) 728 (466) 0.6
Last 486 (396) 548 (507) 0.5
Outcomes, n (%)
Severe infection 3 (20) 9/36 (25) 0.7
Pneumothorax 2 (13.3) 1/38 (2.6) 0.2
Pulmonary thromboembolism 1 (6.7) 0 0.3
Myocardial infarction 1 (6.7) 1/38 (2.6) 0.5
ICU admission 7 (46.7) 33 (76.7) 0.03 (4.7)
Intubation 7 (46.7) 30 (69.8) 0.1
Mortality 7 (46.7) 30 (69.8) 0.1