Changes in immunological parameters
Comparing sIgE levels to storage proteins (Ana o3/Ara h2) from before
OIT (t0) to after up-dosing completion (t1), the CN group showed a
decreasing trend in mean sIgE levels (Fig. 5A). In contrast, the peanut
group (n=27) exhibited varied sIgE level trajectories, resulting in
similar means at both measurement points (t0 and t1).
In the analysis of 21 patients with available data who underwent a
second OFC, the CN group continued its decreasing trend until the end
(t3). Similarly, in the peanut group, after an initial increase, we
observed a decrease in most patients before completing the second OFC
(Figure 5B). No significant differences were observed when comparing
patients who tolerated the final challenge to those who did not.