Statistics
Statistical analysis was performed by using R (version 4.2.2) with
packages ggsurvfit, ggthemes, tidycmprsk, tidyverse22.
Categorical variables were compared using Fischer’s exact test and
continuous variables using the Mann-Whitney U-test. A p-value
<0.05 was considered significant. Time to reach maintenance in
subgroups was compared using the cumulative incidence function and
Gray’s test. Reaching maintenance was considered to be the event of
interest, stopping therapy a competing event and the patients still
continuing therapy were right censored on their last clinical follow-up.