Treatment Period Day Treatment Period Day Treatment Period Day Treatment Period Day Treatment Period Day Treatment Period Day
Day -1 Day -1 Day -1 Day 10 Day 10 Day 10
Rest Cold Stimulus Recovery Rest Cold Stimulus Recovery
Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg)
Zamicastat
119±9
149±15
125±10
124±11
156±15
130±11
Placebo
121±13
150±18
128±14
122±14
158±19
131±13
Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg)
Zamicastat
59±6
78±10
63±7
61±4
82±10
65±7
Placebo
59±8
78±13
63±8
60±5
82±11
65±7
Heart Rate (bpm) Heart Rate (bpm) Heart Rate (bpm) Heart Rate (bpm) Heart Rate (bpm) Heart Rate (bpm) Heart Rate (bpm)
Zamicastat
63±8
70±9
59±6
63±9
73±8
60±9
Placebo
62±7
71±9
59±6
62±6
72±9
59±6
CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure. CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure. CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure. CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure. CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure. CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure. CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure.