Cold Stimulus – Rest Phases Cold Stimulus – Rest Phases Cold Stimulus – Rest Phases
Estimate* One-sided 95% CI p-value
Mean Arterial Pressure (mmHg) -2.62 -4.48 0.025
Cardiac Output (L/min) 0.02 -0.26 0.890
Cardiac Index (L/min/m2) 0.02 -0.13 0.827
Stroke Volume (mL) -0.05 -3.31 0.980
Stroke Volume Index (mL/m2) -0.03 -1.63 0.976
Total Peripheral Resistance (mmHg.s/mL) -0.03 -0.07 0.304
Cardiac Contractility (mmHg/s) -43.43 -96.70 0.175
Left Ventricular Ejection Time (ms) -2.33 -5.63 0.236
*Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline. n: number of subjects; PP-PD: per-protocol pharmacodynamics. *Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline. n: number of subjects; PP-PD: per-protocol pharmacodynamics. *Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline. n: number of subjects; PP-PD: per-protocol pharmacodynamics. *Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline. n: number of subjects; PP-PD: per-protocol pharmacodynamics.