Difference cold stimulus – rest Difference cold stimulus – rest
Day -1 Day 10
Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg) Systolic Blood Pressure (mmHg)
Zamicastat
30±11
32±11
Placebo
29±10
36±9
Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg) Diastolic Blood Pressure (mmHg)
Zamicastat
19±6
21±7
Placebo
19±8
22±8
Heart Rate (bpm) Heart Rate (bpm) Heart Rate (bpm)
Zamicastat
8±6
9±7
Placebo
10±6
11±6
CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure; SD: standard deviation CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure; SD: standard deviation CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood pressure; SD: standard deviation