Data analysis
The mouse gene expression profile was analyzed by assessing Fold Change,
and the threshold for screening up-regulated or down-regulated DE genes
were Fold Change ≥ 2, P value < 0.05. Hierarchical clustering
analysis by using R language. GO analysis and Pathway analysis were
performed by using standard enrichment computational methods. The qPCR
data were analyzed by GraphPad Prism 9 (California, USA). Student’s
t-test was used for comparisons between the two groups. A p -value
less than 0.05 indicated statistical significance.