Action target and mechanism of ag85a/b DNA vaccine
Based on the results from our team’s previous pharmacodynamic study(31) and the preceding part above, the 100μg ag85a/b DNA IM and 50μg ag85a/b DNA EP were optimal effective therapeutic doses. Therefore, we analyzed the DE genes in the 100μg DNA IM group and 50μg DNA EP group to explore the action targets and mechanism of the DNA vaccine.