DEG identification, KEGG and GO Enrichment
As displayed in heat map Fig
S1 , there are 108 DEGs in the heat map. KEGG and GO enrichment of DEGs
were fabricated using DAVID online database. As Fig1 (A,B,C)shows, GO consisted of biological process
(BP), cellular components (CC),
molecular functions (MF). BP analysis
of DEGs mainly shows signal transduction, positive regulation of
inflammatory response and chemokine production. For CC terms, DEGs were
enriched mainly in cytoplasm, membrane, and cytosol; while in protein
binding, protein kinase binding, Calcium ion binding and collagen
binding for MF. KEGG pathway shows the enrichment of DEGs mainly in
cytokine-cytokine receptor, JAK-STAT signaling pathway and cAMP
signaling pathway (Fig1 D ).