Microarray date and DEGs screen
In this research, GSE68167, a gene expression profile based on GPL6887 Illumina MouseWG-6 v2.0 expression beadchip composed of 18 samples was extracted from GEO database(www.ncbi.nlm.nih.gov), which contains gene expression profiles [20]. From these samples, the macrophage extracted from NR4a1 deficit or wild type mice treated with LPS 8 hours were chosen for analysis by GEO2R. LogFc>1 and P<0.05 were set as threshold to screen out the significant DEGs.