References
1. Moore KJ, Tabas I. Macrophages in the pathogenesis of
atherosclerosis. Cell . 2011;145:341-355.
2. Ryan DG, O’Neill LAJ. Krebs cycle rewired for macrophage and
dendritic cell effector functions. FEBS Lett . 2017;591:2992-3006.
3. Pawlak A, Strzadala L, Kalas W. Non-genomic effects of the
NR4A1/Nur77/TR3/NGFIB orphan nuclear receptor. Steroids .
2015;95:1-6.
4. Rougereau G, Langlais T, Valteau B, Creze M, Soubeyrand M. The ulnar
interosseous tuberosity exists: a radiological and descriptive cadaveric
study. Surg Radiol Anat . 2021;43:1609-1617.
5. Shaked I, Hanna RN, Shaked H, Chodaczek G, Nowyhed HN, Tweet G, Tacke
R, Basat AB, Mikulski Z, Togher S, Miller J, Blatchley A, Salek-Ardakani
S, Darvas M, Kaikkonen MU, Thomas GD, Lai-Wing-Sun S, Rezk A, Bar-Or A,
Glass CK, Bandukwala H, Hedrick CC. Transcription factor Nr4a1 couples
sympathetic and inflammatory cues in CNS-recruited macrophages to limit
neuroinflammation. Nat Immunol . 2015;16:1228-1234.
6. Hanna RN, Shaked I, Hubbeling HG, Punt JA, Wu R, Herrley E, Zaugg C,
Pei H, Geissmann F, Ley K, Hedrick CC. NR4A1 (Nur77) deletion polarizes
macrophages toward an inflammatory phenotype and increases
atherosclerosis. Circ Res . 2012;110:416-427.
7. Xiong Y, Ran J, Xu L, Tong Z, Adel Abdo MS, Ma C, Xu K, He Y, Wu Z,
Chen Z, Hu P, Jiang L, Bao J, Chen W, Wu L. Reactivation of NR4A1
Restrains Chondrocyte Inflammation and Ameliorates Osteoarthritis in
Rats. Front Cell Dev Biol . 2020;8:158.
8. Zhang YJ, Song JR, Zhao MJ. NR4A1 regulates cerebral ischemia-induced
brain injury by regulating neuroinflammation through interaction with
NF-κB/p65. Biochem Biophys Res Commun . 2019;518:59-65.
9. Hamers AA, Vos M, Rassam F, Marinković G, Kurakula K, van Gorp PJ, de
Winther MP, Gijbels MJ, de Waard V, de Vries CJ. Bone marrow-specific
deficiency of nuclear receptor Nur77 enhances atherosclerosis.Circ Res . 2012;110:428-438.
10. Lawrence T. The nuclear factor NF-kappaB pathway in inflammation.Cold Spring Harb Perspect Biol . 2009;1:a001651.
11. Crean D, Murphy EP. Targeting NR4A Nuclear Receptors to Control
Stromal Cell Inflammation, Metabolism, Angiogenesis, and Tumorigenesis.Front Cell Dev Biol . 2021;9:589770.
12. Liebmann M, Hucke S, Koch K, Eschborn M, Ghelman J, Chasan AI,
Glander S, Schädlich M, Kuhlencord M, Daber NM, Eveslage M, Beyer M,
Dietrich M, Albrecht P, Stoll M, Busch KB, Wiendl H, Roth J, Kuhlmann T,
Klotz L. Nur77 serves as a molecular brake of the metabolic switch
during T cell activation to restrict autoimmunity. Proc Natl Acad
Sci U S A . 2018;115:E8017-e8026.
13. Lith SC, de Vries CJM. Nuclear receptor Nur77: its role in chronic
inflammatory diseases. Essays Biochem . 2021;65:927-939.
14. Tavares LP, Negreiros-Lima GL, Lima KM, PMR ES, Pinho V, Teixeira
MM, Sousa LP. Blame the signaling: Role of cAMP for the resolution of
inflammation. Pharmacol Res . 2020;159:105030.
15. Su Y, Ding J, Yang F, He C, Xu Y, Zhu X, Zhou H, Li H. The
regulatory role of PDE4B in the progression of inflammatory function
study. Front Pharmacol . 2022;13:982130.
16. Yougbare I, Keravis T, Lugnier C. NCS 613, a PDE4 inhibitor, by
increasing cAMP level suppresses systemic inflammation and immune
complexes deposition in kidney of MRL/lpr lupus- prone mice.Biochim Biophys Acta Mol Basis Dis . 2021;1867:166019.
17. Kamthong PJ, Wu M. Inhibitor of nuclear factor-kappaB induction by
cAMP antagonizes interleukin-1-induced human
macrophage-colony-stimulating-factor expression. Biochem J .
2001;356:525-530.
18. Cao J, Xu T, Zhou C, Wang S, Jiang B, Wu K, Ma L. NR4A1 knockdown
confers hepatoprotection against ischaemia-reperfusion injury by
suppressing TGFβ1 via inhibition of CYR61/NF-κB in mouse hepatocytes.J Cell Mol Med . 2021;25:5099-5112.
19. Tian H, Chen F, Wang Y, Liu Y, Ma G, Zhao Y, Ma Y, Tian T, Ma R, Yu
Y, Wang D. Nur77 Prevents Osteoporosis by Inhibiting the NF-κB
Signalling Pathway and Osteoclast Differentiation. J Cell Mol
Med . 2022;26:2163-2176.
20. Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky
M, Marshall KA, Phillippy KH, Sherman PM, Holko M, Yefanov A, Lee H,
Zhang N, Robertson CL, Serova N, Davis S, Soboleva A. NCBI GEO: archive
for functional genomics data sets–update. Nucleic Acids Res .
2013;41:D991-995.
21. Dennis G, Jr., Sherman BT, Hosack DA, Yang J, Gao W, Lane HC,
Lempicki RA. DAVID: Database for Annotation, Visualization, and
Integrated Discovery. Genome Biol . 2003;4:P3.
22. The Gene Ontology (GO) project in 2006. Nucleic Acids Res .
2006;34:D322-326.
23. Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes.Nucleic Acids Res . 2000;28:27-30.
24. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N,
Schwikowski B, Ideker T. Cytoscape: a software environment for
integrated models of biomolecular interaction networks. Genome
Res . 2003;13:2498-2504.
25. Milakovic M, Gooderham MJ. Phosphodiesterase-4 Inhibition in
Psoriasis. Psoriasis (Auckl) . 2021;11:21-29.
26. Huang B, Chen Z, Geng L, Wang J, Liang H, Cao Y, Chen H, Huang W, Su
M, Wang H, Xu Y, Liu Y, Lu B, Xian H, Li H, Li H, Ren L, Xie J, Ye L,
Wang H, Zhao J, Chen P, Zhang L, Zhao S, Zhang T, Xu B, Che D, Si W, Gu
X, Zeng L, Wang Y, Li D, Zhan Y, Delfouneso D, Lew AM, Cui J, Tang WH,
Zhang Y, Gong S, Bai F, Yang M, Zhang Y. Mucosal Profiling of
Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and
Therapeutic Pathways. Cell . 2019;179:1160-1176.e1124.
27. Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB
transcription factors in the immune system. Annu Rev Immunol .
2009;27:693-733.
28. Xu F, Wang J, Cao Z, Song M, Fu Y, Zhu Y, Li Y. cAMP/PKA Signaling
Pathway Induces Apoptosis by Inhibited NF-κB in Aluminum
Chloride-Treated Lymphocytes In Vitro. Biol Trace Elem Res .
2016;170:424-431.
29. Ma H, Shi J, Wang C, Guo L, Gong Y, Li J, Gong Y, Yun F, Zhao H, Li
E. Blockade of PDE4B limits lung vascular permeability and lung
inflammation in LPS-induced acute lung injury. Biochem Biophys Res
Commun . 2014;450:1560-1567.
30. Zhou Q, He DX, Deng YL, Wang CL, Zhang LL, Jiang FM, Irakoze L,
Liang ZA. MiR-124-3p targeting PDE4B attenuates LPS-induced ALI through
the TLR4/NF-κB signaling pathway. Int Immunopharmacol .
2022;105:108540.
31. Patiño-Martínez E, Solís-Barbosa MA, Santana E, González-Domínguez
E, Segovia-Gamboa NC, Meraz-Ríos MA, Córdova EJ, Valdés J, Corbí Á L,
Sánchez-Torres C. The Nurr7 agonist Cytosporone B differentially
regulates inflammatory responses in human polarized macrophages.Immunobiology . 2022;227:152299.
32. Wu H, Li XM, Wang JR, Gan WJ, Jiang FQ, Liu Y, Zhang XD, He XS, Zhao
YY, Lu XX, Guo YB, Zhang XK, Li JM.
NUR77 exerts a protective effect
against inflammatory bowel disease by negatively regulating the
TRAF6/TLR-IL-1R signalling axis. J Pathol . 2016;238:457-469.
33. Hamers AA, van Dam L, Teixeira Duarte JM, Vos M, Marinković G, van
Tiel CM, Meijer SL, van Stalborch AM, Huveneers S, Te Velde AA, de Jonge
WJ, de Vries CJ. Deficiency of Nuclear Receptor Nur77 Aggravates Mouse
Experimental Colitis by Increased NFκB Activity in Macrophages.PLoS One . 2015;10:e0133598.
34. Hu YW, Zhang P, Yang JY, Huang JL, Ma X, Li SF, Zhao JY, Hu YR, Wang
YC, Gao JJ, Sha YH, Zheng L, Wang Q.
Nur77 decreases atherosclerosis
progression in apoE(-/-) mice fed a high-fat/high-cholesterol diet.PLoS One . 2014;9:e87313.
35. Guo H, Golczer G, Wittner BS, Langenbucher A, Zachariah M, Dubash
TD, Hong X, Comaills V, Burr R, Ebright RY, Horwitz E, Vuille JA,
Hajizadeh S, Wiley DF, Reeves BA, Zhang JM, Niederhoffer KL, Lu C,
Wesley B, Ho U, Nieman LT, Toner M, Vasudevan S, Zou L, Mostoslavsky R,
Maheswaran S, Lawrence MS, Haber DA. NR4A1 regulates expression of
immediate early genes, suppressing replication stress in cancer.Mol Cell . 2021;81:4041-4058.e4015.
36. Schonthaler HB, Guinea-Viniegra J, Wagner EF. Targeting inflammation
by modulating the Jun/AP-1 pathway. Ann Rheum Dis . 2011;70 Suppl
1:i109-112.
37. Zhang Z, Liu N, Chen X, Zhang F, Kong T, Tang X, Yang Q, Chen W,
Xiong X, Chen X. UCHL1 regulates inflammation via MAPK and NF-κB
pathways in LPS-activated macrophages. Cell Biol Int .
2021;45:2107-2117.
38. Li H, Fan C, Feng C, Wu Y, Lu H, He P, Yang X, Zhu F, Qi Q, Gao Y,
Zuo J, Tang W. Inhibition of phosphodiesterase-4 attenuates murine
ulcerative colitis through interference with mucosal immunity. Br
J Pharmacol . 2019;176:2209-2226.
39. Harant H, Lindley IJ. Negative cross-talk between the human orphan
nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB.Nucleic Acids Res . 2004;32:5280-5290.