3.6 Effects of empagliflozin on cartilage degeneration in mouse OA model
To investigate the anti-osteoarthritic effects of empagliflozin in vivo, DMM-induced OA mouse model was used. The articular cartilage tissue samples from mice in the OA group exhibited typical OA features with reduced abundance of chondrocytes and loss of ECM. However, 4-week intra-articular injection of 5 μM empagliflozin could improve these changes (Figure 6A). The OARSI grade of the OA+Empa group was lower than the OA group with significant difference. The data demonstrated that empagliflozin showed anti-osteoarthritic effect in mouse model.