3.6 Effects of empagliflozin on cartilage degeneration in mouse OA
model
To investigate the anti-osteoarthritic effects of empagliflozin in vivo,
DMM-induced OA mouse model was used. The articular cartilage tissue
samples from mice in the OA group exhibited typical OA features with
reduced abundance of chondrocytes and loss of ECM. However, 4-week
intra-articular injection of 5 μM empagliflozin could improve these
changes (Figure 6A). The OARSI grade of the OA+Empa group was lower than
the OA group with significant difference. The data demonstrated that
empagliflozin showed anti-osteoarthritic effect in mouse model.