Table 1. Comparison between Saracatinib, Nintedanib, Pirfenidone Table 1. Comparison between Saracatinib, Nintedanib, Pirfenidone Table 1. Comparison between Saracatinib, Nintedanib, Pirfenidone Table 1. Comparison between Saracatinib, Nintedanib, Pirfenidone
Comparison aspect Saracatinib Ninetidanib Pirfenidone
Mechanism of action Src kinase inhibitor. Tyrosine kinase inhibitors. TGF-𝛃 and fibronectin inhibitor as well as p38 MAPK in B lymphocytes.
TGF- 𝛃 expression of profibrotic genes. Larger inhibitory effect including ACTA2, COL1A1, and SERPIN1 Inhibits TGF- 𝛃 expression of profibrotic genes. Inhibits TGF- 𝛃 expression of profibrotic genes.
TGF-β-induced Smad3 phosphorylation Inhibitory effect. No effect was found. No effect was found.
Experimental pulmonary fibrosis reduction Better effect. Less effect. Less effect.
Precision cuts lung slices results Better effect in reducing pulmonary fibrosis. Less effect. Less effect.