Abstract
Objective : To determine the relationship between lipid
profile and risks of adverse pregnancy outcomes in pre-pregnant
underweight women.
Design : This study was part of an ongoing cohort study which
Chinese gravidas delivered from January 2015 to December 2016.
Setting : Pre-pregnant body mass index (pre-BMI) was classified
into underweight (<18.5 kg/m2), normal
weight (18.5-22.9 kg/m2) and overweight/obesity (≥23
kg/m2).
Population : There’re 1203 underweight- women, 3281
normal-weight women and 1209 overweight women met the criteria.
Methods: Data of 6233 women and medical information
including lipid concentrations, pregnancy complications, pregnancy and
perinatal outcomes were analyzed.
Results : The proportion of underweight women 19.2% and
overweight/obese women19.4% was similar in South China. Serum TC level
of underweight women was significantly higher than overweight/obese
women (p < 0.001). After adjusting for maternal age,
underweight women with high TC level had significantly higher occurrence
of LGA [OR=2.24, 95%CI (1.08, 4.63)], and lower occurrence of SGA
[OR=0.71, 95%CI (0.59, 0.85)], while there were no significant
associations between TC and LGA or SGA in other groups.
Conclusion : Underweight women with high TC had higher
occurrence of LGA, while there was no association between TC levels and
LGA in normal and overweight/obese women. Thus, we should recommend
underweight women to manage the lipid.
Funding: This work was supported by the National Natural
Science Foundation of China (Grant No: 81771606), Shenzhen Science and
Technology Innovation Commission (Grant No: JCYJ20170817172241688,
JCYJ20180228163459314), and Clinical Medical Project 5010 of Sun Yat-sen
University, China (Grant No: 2012004).
Key words: underweight; cholesterol; LGA; overweight;