AUCtau area under the plasma concentration time curve from the time of
dosing over one dosing interval (24 h QD or 12 h BID) at steady state;
Cmaxss, maximum plasma concentration at steady state; Cminss minimum
plasma concentration at steady state; CV, coefficient of variation
(calculated using log transformed data); SD, standard deviation; tmaxss,
time to Cmaxss
bFluctuation was calculated as 100*(Cmax minus
Cmin/Cavg), with Cavg derived from AUC from dose time to tau divided by
tau)
Table 3: σ1 Receptor occupancy
estimates and MR309 PK (PET study)