|
MR309 200 mg BID |
|
(N=16) |
MR309 400 mg QD |
|
(N=16) |
|
|
AUCtau (ng.h/mL) |
AUCtau (ng.h/mL) |
AUCtau
(ng.h/mL) |
Geometric mean (log SD)
|
31279 (0.2)
|
58412 (0.2)
|
CV (%)
|
23.9
|
20.9
|
Arithmetic mean (SD)
|
32113 (7744)
|
59572 (12097)
|
Median (min, max)
|
33378 (20631, 52275)
|
60822 (39532)
|
Cmaxss (ng/mL) |
Cmaxss (ng/mL) |
Cmaxss
(ng/mL) |
Geometric mean (log SD)
|
4143 (0.2)
|
5222 (0.2)
|
CV (%)
|
17.2
|
18.3
|
Arithmetic mean (SD)
|
4200 (719)
|
5304 (969)
|
Median (min, max)
|
4395 (3010, 5940)
|
5300 (3920, 7140)
|
Cminss (ng/mL) |
Cminss (ng/mL) |
Cminss
(ng/mL) |
Geometric mean (log SD)
|
1915 (0.3)
|
1764 (0.3)
|
CV (%)
|
29.8
|
29.9
|
Arithmetic mean (SD)
|
1991 (580)
|
1832 (493)
|
Median (min, max)
|
2055 (1070, 3510)
|
1870 (856, 2860)
|
tmaxss (h) |
tmaxss (h) |
tmaxss
(h) |
Arithmetic mean (SD)
|
1.28 (0.47)
|
1.40 (0.38)
|
Median (min, max)
|
1.00 (0.67, 2.33)
|
1.33 (0.63, 2.0)
|
Fluctuation (%)a |
Fluctuation
(%)a |
Fluctuation
(%)a |
Arithmetic mean (SD)
|
86 (22)
|
145 (49)
|