AUCtau area under the plasma concentration time curve from the time of dosing over one dosing interval (24 h QD or 12 h BID) at steady state; Cmaxss, maximum plasma concentration at steady state; Cminss minimum plasma concentration at steady state; CV, coefficient of variation (calculated using log transformed data); SD, standard deviation; tmaxss, time to Cmaxss
bFluctuation was calculated as 100*(Cmax minus Cmin/Cavg), with Cavg derived from AUC from dose time to tau divided by tau)
Table 3: σ1 Receptor occupancy estimates and MR309 PK (PET study)