2.2.3 Continuous administration
There were 3 dose open groups for continuous administration, with 6 cases in each group, and the time of continuous administration was 24 hours. After the administration, the subjects were discharged after 2 days of hospitalization, and the trial ended after the 28th day. In each dose group, the dose of intravenous bolus (bolus 30 seconds or more) was 0.4 mg/kg, and the increasing range of maintenance dose was 0.15, 0.30 and 0.45 mg/kg/h. One subject in each group was first enrolled, and the remaining subjects were then enrolled after observing that there was no safety problem at least 48 hours after the end of the administration. It was confirmed that there was no safety problem after the last subject in the previous dose group had completed the observation to at least the 7th day, then the subjects were entered for the next dose group. Supervising and guiding the process of drug clinical trials was performed by establishing a data and safety monitoring committee. The continuous administration process was shown in Figure 2.