2.1 Subjects
Healthy, nonsmoking men or women aged 18–45 years with a body mass
index of 19–26 kg /m2 (Weight≥50kg) were eligible for
inclusion in the study. The health status was determined by a prestudy
medical history, physical examination and clinical laboratory
evaluations. Women who were nursing or pregnant and subjects who were
infected with human immunodeficiency virus, hepatitis B, hepatitis C
viruses or syphilis
were
excluded from the study. The subjects were not allowed to consume
cigarette, alcohol or grapefruit-containing products to screening and
during admission and follow-up. The subjects who have blood donation
history or significant blood loss in the past 3 months (≥400ml) were
excluded from the study.