2.4.2 Pharmacokinetic study of continuous administration dose
Eighteen subjects in the 3 dose groups of 0.15, 0.30 and 0.45mg/kg/h participated in the pharmacokinetics analysis of continuous administration dose. Serum was taken within 5 min before administration, 5 min, 30 min, 4h, 8h, 12h and 24h after the start of administration, 5 min, 20 min, 40 min, 1h, 1.5h, 2h, 3h, 4h, 6h, 8h, 12h, 24h after the end of the administration to test the blood drug concentration. In the 0.30 mg/kg/h dose group, plasma was also taken at 5 min, 8 h, 24 h and 5 min after the end of administration to test the blood drug concentration, and urine was collected before administration, 0-4h, 4-8h, 8-12h, 12-16h, 16-20h, 20-24h after administration start, 0-4h, 4-8h, 8-12h, 12-16h, 16-20h, 20-24h, 24-32h, 32-40h, 40-48h after the end of the administration to test the urine drug concentration.