2.1 Subjects
Healthy, nonsmoking men or women aged 18–45 years with a body mass index of 19–26 kg /m2 (Weight≥50kg) were eligible for inclusion in the study. The health status was determined by a prestudy medical history, physical examination and clinical laboratory evaluations. Women who were nursing or pregnant and subjects who were infected with human immunodeficiency virus, hepatitis B, hepatitis C viruses or syphilis were excluded from the study. The subjects were not allowed to consume cigarette, alcohol or grapefruit-containing products to screening and during admission and follow-up. The subjects who have blood donation history or significant blood loss in the past 3 months (≥400ml) were excluded from the study.