2. The exigency of COVID-19 vaccine
Since the outbreak of SARS-CoV2 infection, there has been a general
mobilization of governments, organizations and research institutes to
achieve effective treatment against the contagious disease. Existing
drugs and treatment strategies save patients’ lives to some extent, but
our main need is to achieve a successful drug that can be at least 95%
operative against this pandemic. For setting up the arrant chaos, we
have no choice unless to obtain an immunogenic, safe and cost-effective
vaccine that covers a wide range of people all around the world as soon
as possible. Bedsides, given the human history of dealing with
infectious diseases such as mumps, measles, Spanish flu and SARS,
general vaccination is the only way to get rid of COVID-19 pandemic and
achieve herd immunity that subsequently reduce the economic, social and
psychological pressures on human society. The implementation of
effective vaccine strategies contains several aspects that should be
carefully considered. Therefore, in the current paper, we intend to
explain the immunological and non-immunological characteristics of
COVID-19 vaccine design, review the available data from related
preclinical and clinical trials and assess the advantages and
disadvantages of pioneering COVID-19 vaccine platforms.
3. Immune arms against
COVID-19