5. The main steps of vaccine design
Vaccine design generally involves going through three stages of
appropriate antigen prediction, vaccine platform determination and the
suitable vaccination route along with
effective regimen [8]. The
immunostimulatory strength of the viral antigen, necessity for adjuvant
and the nature of the primed protective immune responses depends
primarily on vaccine platform. These features also influence the
competency of a vaccine candidate for a special route of administration
and the need for a booster dose in order to establishing a durable
protective immune response. Moreover, certain types of vaccines such as
live attenuated or mucosal vaccination should be presented with more
pedant safety analysis.