5.1. Antigen prediction
The S, E, M and N are the main structural proteins of the coronavirus
virions that the N proteins encompass a long RNA genome while the
remnant immerge in lipid bilayer viral envelope. Based on previous
experience with the SARS vaccine, it has been shown that only antibodies
against various epitopes of the S protein neutralized the viral
particles [36]. Therefore, the new SARS-CoV2 vaccines have focused
at least on priming immune responses to some parts of the S protein
especially S1 subunit and the RBD domain. However emerging
non-neutralizing antibodies against all the structural and
non-structural proteins and the subsequent disruptive ADE phenomenon
saber rattling as the main obstacle in effective vaccination. So,
considering the most constitutive as well as conserved viral proteins
such as RNA polymerase [37] in vaccine design will provide a more
confidential vaccine candidate and probably relieve us a lot of worries
about possible future coronavirus infections as well.