BDL significantly increases TGFβ1 expression in female rats
PDGF-BB possesses mitogenic(24), differentiation-promoting (25),
chemotactic(26) and angiogenic(27) properties, and is produced by
osteoblasts, platelets and monocytes/macrophages, PDGF-BB and
TGF-β1both
activate the HSCs and promote liver fibrosis(28). TGF-β1is ubiquitously
present in both normal cells and transformed cells and almost all cells
have receptors for it(22). IFN-γ plays critical roles in
promoting pathologic inflammatory processes(29). In Table 5, the levels
of PDGF-BB, IFN-γ and TGF-β 1 in the liver of female and male rats
showed no significant difference; BDL or TAA slightly decreased PDGF-BB
and increased in TGF-β 1 but had no obvious effect on IFN-γ. The
increase in TGF-β 1 in livers of female rats with BDL was significantly
greater than that with TAA treatment (Figure 6).