Ethics approval:
All animal experiments were performed in accordance with the guidelines
of the Ethical Committee for the Care and Welfare of Laboratory Animals
from the Sichuan province government.
Abbreviations: BDL, bile duct ligation; α-SMA, α-smooth muscle
actin; TAA, thioacetamide; HBV, hepatitis B virus; HCV, hepatitis C
virus; NASH, nonalcoholic steatohepatitis; HSCs, hepatic stellate cells;
NK, natural killer; TNFα, tumor necrosis factor α; ILs, interleukins;
TGF-β, transforming growth factor β; ALT, alanine aminotransferase; AST,
aspartate amino transferase; ALP, alkaline phosphatase; TBIL, total
bilirubin; DBIL, direct bilirubin; H&E, hematoxylin and eosin; SABC,
streptavidin-biotin complex; DAB, 3,3’-diaminobenzidine; PDGF,
platelet-derived growth factor; IFN, interferon; TMB,
Tetramethylbenzidine; MCP-1, monocyte chemoattractant protein-1; MIP,
macrophage inflammatory protein; MFI, median fluorescent intensity;
EMCs, extracellular matrix components; FN, fibronectin; LN, laminin;
NLRP, NOD-like receptor protein;