BDL and TAA have similar inhibitory effects on signaling pathway
components except p-p70S6K in the livers of rats
Many signaling pathway components, such as CREB, c-JNK, NF-κB, P38MAPK,
ERK1/2,
Akt,
p70S6K, STAT3 and STAT5, are involved in the occurrence, development and
dissolution of liver fibrosis(30-37). Activation of the signaling
pathways occurs via phosphorylation of these key proteins, so the levels
of phosphorylated protein represent the level of signaling pathway
activation.
As shown as Table 6, p-CREB, p-JNK, p-NF-κB, p-P38MAPK, p-ERK1/2, p-Akt,
p-p70s6k, p-STAT3 and p-STAT5 expression was significantly higher in the
livers of female rats than those of male rats; BDL significantly
decreased p-NFκB p-P38MAPK, p-Akt, p-STAT5 expression and increased
p-p70s6k expression in the livers of female rats. TAA significantly
decreased the levels of p-CREB, p-JNK, p-NFκB, p-Akt, p-p70s6k, p-STAT3
and p-STAT5 in male rats but had no significant effect on the levels of
p-P38MAPK and p-ERK1/2 (Figure7).