Key Results:
The levels of transaminases in serum and hydroxyproline and α-smooth
muscle actin in the liver were remarkably increased in both models,
although the degree of liver fibrosis was more severe in thioacetamide
rats than in BDL rats. However, the levels of IL-1α, IL-4, IL-10, TNFα,
MCP-1, PDGF-BB, p-Akt and p-STAT5 decreased, and the levels of IL-18,
TGFβ1 and p-p70s6k increased in the livers of BDL rats, while the levels
of IL-1α, IL-4, IL-10, IL-1β, IL-6 and IL-12p70, TNFα, MCP-1, PDGF-BB,
p-CREB, p-JNK, p-NFκB, p-Akt, p-p70s6k, p-STAT3 and p-STAT5 decreased,
and the levels of IL-18 and TGF-β1 increased in the livers in
thioacetamide rats.