Conclusions
For the first time, we have confirmed the effect of Rh genotype on human viability (health) in the sample of subjects directly Rh-genotyped by a molecular method. We demonstrated that the effect is modulated by the sex of the subjects – Rh-positive women had worse and Rh-positive men had better physical health than Rh-negative homozygotes. These results strongly suggest that the performance of Rh-positive subjects depends on heterozygote/homozygote ratio, which could strongly vary depending on the frequency of the Rh-negative allele in the general population and the method of recruitment of participants to the study. This strongly underlines that the performance and health of subjects with different Rh-genotypes, not just phenotypes, should be compared in future studies.