WHAT THIS STUDY ADDS ABOUT THIS SUBJECT
• We quantified the proportion of cefoperazone and sulbactam removed by TPE. Cefoperazone is more likely to be removed than sulbactam.
• No significant differences were observed in PK when compared with and without TPE.
• Dosage adjustment after TPE is unnecessary, and the time interval between TPE and drug infusion is negligible.

Abstract

AIMS
The aim of this study was to investigate the pharmacokinetics of CFP and SUL in critically ill thrombotic thrombocytopenic purpura (TTP) patients undergoing TPE.