CONCLUSIONS
A single plasma volume TPE does not remove clinically significant
amounts of CFP and SUL. Dosage adjustment in critically ill TTP patients
after the procedure is not necessary. CFP is more likely to be removed
than SUL during TPE due to its small Vd and high protein binding (Pb).
Elevated plasma drug concentration due to organ dysfunction may permit
more drug removal during TPE.
Keywords: Pharmacokinetics; Thrombotic Thrombocytopenic
Purpura; Cefoperazone; Sulbactam;
Therapeutic Plasma Exchange; Removal;
Abbreviations: TTP, thrombotic thrombocytopenic purpura; TPE,
therapeutic plasma exchange; CFP,
cefoperazone; SUL, sulbactam; PV, plasma volume; Pb, protein binding;
Vd, volume of distribution; AUC, area under concentration-time curve;
Kel, elimination rate constant; CL, drug clearance; MOF: multiple organ
failure.