RESULTS
Specific pharmacokinetic parameters were calculated to evaluate the effect of TPE on CFP and SUL. The amount of drug eliminated during TPE (QPE) were 395.75±147.38 and 35.25±11.32 mg, respectively. Percentage eliminated by TPE (fe %) were 11.38±3.18% and 2.74±1.13%, respectively. Calculated percentages of total drug clearance by TPE (%CLPE) were 27.71±10.8% and 6.16±2.16%, respectively. There were no significant differences in pharmacokinetic parameters (AUC0-8, Vd, T1/2a) between session I and session II for both CFP and SUL.