WHAT THIS STUDY ADDS ABOUT THIS SUBJECT
• We quantified the proportion of cefoperazone and sulbactam removed by
TPE. Cefoperazone is more likely to be removed than sulbactam.
• No significant differences were observed in PK when compared with and
without TPE.
• Dosage adjustment after TPE is unnecessary, and the time interval
between TPE and drug infusion is negligible.
Abstract
AIMS
The aim of this study was to investigate the pharmacokinetics of CFP and
SUL in critically ill thrombotic thrombocytopenic purpura (TTP) patients
undergoing TPE.