Conclusion
In general, we firstly describe the pharmacokinetics of CFP and SUL in critically ill TTP patients undergoing TPE. Results confirmed that Vd and Pb are the two dominant factors determining drug elimination by TPE. CFP is more likely to be removed than SUL during TPE due to its a small Vd and high Pb. However, the amount of CFP and SUL removed by TPE may not be clinically significant, and dosages should not be adjusted in critically ill TTP patients undergoing TPE.