3.4 Duration between last prescription and index date and risk
of UGIB
Current users of fluoxetine, defined as individuals with an interval of
0–14 days between date from last prescription and index date, had an
elevated risk of UGIB, compared with non-users of fluoxetine (i.e.,
users of other classes of SSRIs) (adjusted OR: 1.69, 95% CI:
1.08–2.63, Figure 2). Moreover, recent users (with the last
prescription on 15–29 days before index date) had an elevated risk of
UGIB (adjusted OR: 1.85, 95% CI: 1.10–3.10). However, a last
prescription for fluoxetine 30 days before index date was not associated
with UGIB risk. No association was observed for other individual SSRIs.
DISCUSSION