Abbreviations: CI: confidence interval; MD: mean difference; WMD:
weighted mean difference
Figure 1. Flow diagram of study selection.
Figure 2. Risk of bias summary.
Figure 3. Forest plot of general meta-analysis of ICP reduction
from pretreatment to first reported records after treatment, comparing
mannitol and HTS.
Figure 4. Forest plot of reduction of ICP at different time
points, comparing mannitol and HTS.
Figure 5. Forest plot of eligible secondary outcomes (CPP, MAP,
Serum Sodium, Serum Osmolarity, HCT, HR), comparing mannitol and HTS.
Figure 6. Assessment of publication bias by a contour-enhance
funnel plot.
Supplementary material 1. Data of contour-enhance funnel plot
Supplementary material 2. Egger’s test
Supplementary material 3. AMSTAR 2 of previous systematic
reviews
Y: yes; N: no; PY: Partial Yes.
Red-labled means critical domains of AMSTAR 2.