Bias assessment
Risk of bias assessment uncovered numerous concerns regarding the study’s methodology, with all papers demonstrating “some concerns” (5) to “high” (2) risk. Overall quality of trials varied considerably, with incomplete reporting of methods and results inhibiting a thorough bias assessment. No trials were registered in Clinicaltrials.gov, meaning comparison of planned and reported outcomes was not possible. Only Maw described 6 patients lost to follow-up, and no studies described an intention to treat analysis. Risk of bias assessment is summarised in table 5 and figure 2 .