Introduction
Since the first case detected in the city of Wuhan, Coronavirus disease 2019 (COVID-19) cases have been increasing exponentially and declared as a global pandemic (1,2). This virus causes the infection known as severe acute respiratory syndrome 2 (SARS-CoV-2) and produces in most cases respiratory symptoms progressing from pneumoniae to acute respiratory distress syndrome. However, it is well known that the virus can be expressed as extrapulmonary manifestations (3). Some prospective observational studies have already described cardiac involvement such as arrhythmias, acute myocardial injury, and Heart failure (HF) (4). Specifically, some cases of pericarditis, cardiac effusion and pericardial tamponade have been described (5,6). Highlighting the importance to consider this pathology on a patient with COVID-19 who persists with dyspnea prior to discharge. We present a case of COVID-19 readmission due to severe pericardial effusion that progressed to cardiac tamponade. This case wants to show the importance of considering cardiac manifestations as a cause of dyspnea in patients with COVID-19.