Validation and clinical application of a method to quantify
efavirenz incervicovaginal secretions
from flocked swabs using LC-MS/MS
Adeniyi Olagunju1,2*, Jacinta
Nwogu1,3, Oluwasegun Eniayewu2,4,
Shakir Atoyebi1,2, Alieu Amara1,
John Kpamor5**, Oluseye Bolaji2;
Ebunoluwa Adejuyigbe6, Andrew Owen1,
Saye Khoo1
1Department of Pharmacology and Therapeutics,
University of Liverpool, Liverpool, UK; 2Department of
Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo
University, Ile-Ife, Nigeria; 3 Department of
Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan,
Ibadan, Nigeria; 4Department of Pharmaceutical and
Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of
Ilorin, Ilorin, Nigeria; 5Federal Medical Centre,
Makurdi, Nigeria; 6Department of Paediatric and Child
Health, Obafemi Awolowo University, Ile-Ife, Nigeria
Keywords: efavirenz, cervicovaginal fluid, flocked swab,
LC-MS/MS
*Correspondence: Adeniyi Olagunju, PhD. Department of
Pharmacology and Therapeutics, University of Liverpool, Liverpool,
United Kingdom (Tel: +4479 4932 9633; e-mail:
olagunju@liverpool.ac.uk).
**Principal Investigator: The authors confirm that the site
principal investigator for this paper is Dr John Kpamor and that he had
direct clinical responsibility for the patients.