Validation and clinical application of a method to quantify efavirenz incervicovaginal secretions from flocked swabs using LC-MS/MS
Adeniyi Olagunju1,2*, Jacinta Nwogu1,3, Oluwasegun Eniayewu2,4, Shakir Atoyebi1,2, Alieu Amara1, John Kpamor5**, Oluseye Bolaji2; Ebunoluwa Adejuyigbe6, Andrew Owen1, Saye Khoo1
1Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK; 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria; 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria; 4Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria; 5Federal Medical Centre, Makurdi, Nigeria; 6Department of Paediatric and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria
Keywords: efavirenz, cervicovaginal fluid, flocked swab, LC-MS/MS
*Correspondence: Adeniyi Olagunju, PhD. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom (Tel: +4479 4932 9633; e-mail: olagunju@liverpool.ac.uk).
**Principal Investigator: The authors confirm that the site principal investigator for this paper is Dr John Kpamor and that he had direct clinical responsibility for the patients.