Serelaxin exhibits its anti-inflammatory effects through
activating PPAR-γ
Then, we studied the mechanism of serelaxin inhibition of P65 NF-κB
expression. In order to elucidate the anti-inflammatory mechanism of
serelaxin on LPS-induced inflammation, the effects of serelaxin on PPAR-γ
expression were tested. Compared with the control group, expression of
PPAR-γ reduced with LPS treatment. However, treatment of serelaxin
upregulated the expression of PPAR-γ (Fig. 7E and F ). Furthermore, the
increasing of serelaxin on PPAR-γ expression were prevented by PPAR-γ
inhibitor GW9662.