KEY RESULTS
Serelaxin inhibited LPS-induced IL-1β, IL-6 and TNF-α, α-SMA, collagen
I/III, and elevated IL-10, MMP-2 and MMP-9 expression. And, LPS-induced
activation of NF-κB pathways was suppressed by serelaxin treatment.
Substantially, Further research demonstrated that serelaxin elevated the
expression of PPAR-γ and PPAR-γ inhibitor GW9662 could reverse the
inhibition of serelaxin on IL-1β, IL-6,TNF-α production.