PPARγ inhibitor reversed the anti-inflammatory effects of serelaxin
In order to prove the anti-inflammatory mechanism of serelaxin, PPARγ was inhibited by GW9662. As shown in Fig.7, GW9662 significantly inhibited the expression of PPARγ. However, inhibitory effect of serealxin on IL-1β, IL-6 and TNF-α was reversed by GW9662(Fig. 5). These results demonstrated that serelaxin exerts an anti-inflammatory effect by activating PPARγ pathway.