GHD VS Normotensive
Ten studies (304181 twin pregnancies) explored the risk of birthweight discordance (≥15%) in twin pregnancies complicated by GHD compared with Normotensive group. Considering all twin pregnancies, the risk of birthweight discordance was significantly higher in twin pregnancies with GHD (OR 1.65, 95% CI 1.41-1.94; I2 =57%). After stratified by twin chorionicity, birthweight discordance was associated with an increased risk for GHD (OR 2.51, 95% CI 2.01-3.14; I2 =0%) in DC twin pregnancies. However, no significant association was observed in MC group (OR 1.14, 95% CI 0.76-1.72; I2 =0%). (Figure 1)