All cases (N=631) No-Covid patients (N=265) Covid patients (N=366)
P
Seriousness – no. (%) Seriousness – no. (%)
Serious cases 454 (72) 153 (58) 301 (82) <0.001
Deaths 30 (5) 8 (3) 22 (6) .058
Gender – no. (%) Gender – no. (%)
Females Males Unknown 355 (56) 267 (42) 9 (1) 219 (83) 39 (15) 7 (3) 136 (37) 228 (62) 2 (1)
<0.001
Age – yr. Age – yr.
Median (IQRa) 59 (45 – 70) 50.0 (36.8 – 65.0) 61.0 (51.0 – 72.0) <0.001
Age group – no. (%) Age group – no. (%)
Newborn Breastfed Child Adolescent Adult > 65 years Unknown 4 (1) 2 (0) 8 (1) 3 (1) 395 (63) 198 (31) 21 (3) 4 (2) 1 (0) 5 (2) 2 (1) 180 (68) 55 (21) 18 (7) 0 (0) 1 (0) 3 (1) 1 (0) 215 (59) 143 (39) 3 (1)
Daily HCQ dose – no. (%) Daily HCQ dose – no. (%)
Low, < 400 mg /d Medium, 400-600 mg/d High, 800 mg/d Unknown 126 (20) 209 (33) 37 (6) 259 (41) 111 (42) 47 (18) 0 (0) 107 (40) 15 (4) 162 (44) 37 (10) 152 (41)
<0.001
Total HCQ dose – mg Total HCQ dose – mg
Median (IQR) 2,800 (1,600 - 5,900) 21,600 (5,400 – 87,800) 2,400 (1,600 – 3,100) <0.001
Total HCQ dose – no. (%) Total HCQ dose – no. (%)
Low (≤ 50.000 mg) Medium (51.000-200.000 mg) High (> 200.000 mg) Unknown 271 (42.9) 14 (2.2) 16 (2.5) 330 (52.3) 63 (23.8) 14 (5.3) 16 (6.0) 172 (64.9) 208 (56.8) 0 (0) 0 (0) 158 (43.2)
<0.001
Length of treatment with HCQ – days, no. (%) Length of treatment with HCQ – days, no. (%)
Median (IQR) 7 (5 - 17) 65 (18 - 365) 6 (4 - 7) <0.001
Short (≤ 10 days) Medium (11-90 days) Long (> 90 days) Unknown 283 (44.8) 73 (11.6) 61 (9.7) 214 (33.9) 20 (7.5) 51 (19.2) 59 (22.3) 135 (50.9) 263 (71.9) 22 (6.0) 2 (0.5) 79 (21.6)
<0.001
Indications – no. (%) Indications – no. (%)
Covid19 Arthropathy Lupus erythematosus Sjögren’s syndrome Dermatomyositis Connective tissue disorder Lichen Alopecia Antiphospholipid syndrome Collagen disorder Polymyositis Cutaneous sarcoidosis Othersb Unknown 366 (58) 90 (14) 84 (13) 9 (1) 6 (1) 5 (1) 5 (1) 5 (1) 3 (1) 2 (0) 2 (0) 2 (0) 10 (2) 42 (7) 0 (0) 90 (34) 84 (32) 9 (3) 6 (2) 5 (2) 5 (2) 5 (2) 3 (1) 2 (1) 2 (1) 2 (1) 10 (3) 42 (16) 366 (100) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
Total drugs - no. (%) Total drugs - no. (%)
Median (IQR) 1 drug (only HCQ) 2-10 drugs > 10 drugs 3.0 (2 - 4) 157 (24.9) 456 (72.3) 18 (2.9) 1.0 (1 - 4) 136 (51.3) 125 (47.2) 4 (1.5) 4.0 (3 - 5) 21 (5.7) 331 (90.4) 14 (3.8)
<0.001
More frequent pharmacologic groups – no. (%) More frequent pharmacologic groups – no. (%) More frequent pharmacologic groups – no. (%)
antibacterials antivirals corticosteroids immunosuppressants (IL inhib.) immunosuppressants antithrombotics analgesics drugs for peptic ulcer 79 (44) 204 (32) 119 (19) 85 (13) 76 (12) 62 (10) 60 (10) 44 (7) 10 (4) 0 (0) 63 (24) 5 (2) 57 (22) 18 (7) 23 (9) 18 (7) 269 (73) 204 (32) 119 (19) 85 (13) 76 (12) 62 (10) 60 (10) 44 (7)