Network diagram
As shown in figure 3, a network diagram was conducted based on the six interventions (Baclofen, Bupropion, Naltrexone, Topiramate, Varenicline, and Placebo). A total of five direct comparisons and 10 indirect comparisons were included in this diagram. Varenicline vs placebo occupied a larger proportion, and the placebo group accounted for the largest sample size.