Safety
As shown in table 2, the adverse
events reported in some studies were used to assess the safety of
specific drugs. From the results, three drugs (Varenicline, Topiramate,
and Bupropion) reported the symptoms and cases of adverse reactions in
different groups. These adverse symptoms mainly included nausea,
insomnia, headache and depression, etc. From the statistical difference,
paresthesia caused by Topiramate, mild nausea caused by Varenicline, and
insomnia caused by Bupropion reported more cases than placebo group. For
other symptoms, there was no obvious difference between drugs and
placebo.