Serious adverse events related to trial:
Serious adverse events related to trial were classified by the authors of each trial.
Total number of patients with SAE related to trial was 14 patients out of 261 patients for the Cryoablation group and 10 patients out of 260 patients for the AAD group.
The meta-analysis generated, a pooled RR for overall patients with a minimum of 1 SAE of 1.40 for CA Versus AAD (95% CI 0.64, 3.09, P=0.4, I2=38%) using the fixed effect model, out of the two included studies (n=521) (fig. 4)