Author Contributions
Patrick Ip is the Principal Investigator of the Collaborative Research Fund, the funding source of this study. Patrick Ip, Hing Wai Tsang, and Gilbert T Chua contributed to the study conception and research design. Mike Kwan, Kelvin To, Wilfred Wong, and Wing Hang Leung contributed to the data collection and analysis. Patrick Ip, Hing Wai Tsang, Gilbert T Chua, Yu Lung Lau, WW Tu, and Janette Kwok contributed to the data interpretation. Hing Wai Tsang, Xiwei Wang and Yanmei Zhang contributed to the experimental sample preparation and processing. Hing Wai Tsang and Gilbert T Chua drafted the manuscript and all co-authors commented and contributed to the revisions and final manuscript.