3.1 Involvement of ocular surface and appendages
The most common symptoms are discomfort of the eyelids, conjunctiva and lacrimal gland organs, including dry eye [2], nasolacrimal duct obstruction [16], lacrimal duct obstruction [16-18], erosive conjunctivitis and punctate stenosis [4], corneal epithelial lesions [19, 20], and limbal stem cell deficiency [3]. The obstruction of nasolacrimal duct may be related to the interstitial fibrosis of lacrimal duct mucosa [16]. And conjunctiva, keratopathy and dry eye may be related to the cytotoxicity of the drug. The drug inhibits cell proliferation in the cornea and eye surface, leading to stem cell dysfunction, and then triggers inflammation of the conjunctiva and epithelial defects [19]. However, the mechanisms of the injury of ocular surface and accessory organ is still needed to be investigated.