Abstract
Background: Preoperative inflammatory indicators had been found
to correlate with tumor prognosis, contributing to patient
stratification and precise treatment.
Objectives: The proportion of Platelet-lymphocytes ratio was
associated with the progression of laryngeal cancer, however the results
were not consistent. Therefore, we used a meta-analysis to evaluate the
prediction of preoperative Platelet-lymphocytes ratio (PLR)for
laryngeal cancer outcomes.
Methods: We searched WOS, Ovid, Pubmed and The Cochrane library
for articles on PLR and Overall Survival(OS) and Progression-free
survival(PFS) of patients with laryngeal cancer, from January 1, 2000 to
May 1, 2021. State 12.0 was used for conbination analysis. Fixed effects
model and random effects model were used to calculated HR and 95%CI.
Preferred reporting items that follow systematic review and
meta-analysis (PRISMA) guidelines.
Results: This meta-analysis eventually included 1,711 cases
from 7 studies. The merge OS,
HR=1.70, 95%CI 1.11-2.61; PFS, HR=1.34, 95%CI 0.47-3.81. Subgroup
analysis included sample size, cut-off, treatment, variable and disease
stage showed that a poor OS in patients with increased PLR.
Conclusion: Higher PLR may be an adverse prognostic factor for
laryngeal cancer. PLR could be obtained by regularly preoperative test,
it could help surgeons to evaluate the prognosis of patients with
laryngeal cancer.
Key words: Laryngeal cancer; Platelet-lymphocytes ratio;
Meta-analysis; System review.