Clinical data collection and analysis
Patients’ data was collected from the time of antifungal treatment initiation until nebulized voriconazole was stopped due to recovery, death or other reasons using electronic medical records. Information about antifungal treatment was obtained from the prescription software used in our center. Samples used to identify fungal pathogens included sputum, bronchoalveolar lavage, or aspirate or tracheal aspirate.
Voriconazole concentration in plasma was determined in the Biochemistry Department using high-performance liquid chromatography (HPLC) with fluorescence.
Descriptive statistics are expressed as medians and range (min-max) or absolute numbers (percentages) for categorical variables.