Voriconazole solution
Voriconazole solution for nebulization was prepared in vertical laminar flow microbiological safety cabinet in the Hospital Pharmacy Department, following the Good Manufacturing Practice and dispensed as monodose syringes ready to use. Different brands of voriconazole were used, depending on the availability (Table 1).
Voriconazole solution was compounded according to available literature (11). An osmometer (A2O, Advanced Instrument INC) and a pH meter (Testo 206) were used to characterize the solution.