Voriconazole solution compounding and characterization
Voriconazole vials containing 200 mg of powder for solution for infusion were diluted with 19ml of sterile water for injection; syringes containing 40 mg of voriconazole in 4ml were obtained. Voriconazole powder from Teva® was diluted in sodium chloride 0.9% in order to reach an acceptable osmolarity. Characterization of the compounded voriconazole solutions is shown in Table 1, all of them were considered appropriate for nebulization based on published literature (12-17).
It was estimated that the voriconazole solution was chemically stable for 30 days refrigerated (2-8ºC) and 90 days frozen (-20ºC) (11, 13). Biological stability was calculated based on the Good Manufacturing Practice in Hospital Pharmacy Services (13), since it was shorter, it defined the voriconazole solution valid period as 9 days refrigerated and 45 days frozen.