Acknowledgements
We thank Bengt Sennblad and Payam Emami at the National Bioinformatics Infrastructure Sweden at SciLifeLab for fruitful discussions and help with the data analyses. We would like to acknowledge support from Science for Life Laboratory, the National Genomics Infrastructure and NGI for providing assistance in massive parallel sequencing. This work was supported by the Swedish Research Council (grants no. 2017-04159 and 2022-03343 to PL), the Research Council Formas (grant no. 2017-00965 to PL), the Knut and Alice Wallenberg Foundation (grant no. 2012.0058) and the Carl Tryggers Stiftelse (grant no. CTS20-242). The computation was enabled by resources in project SNIC 2022/22-87 provided by the Swedish National Infrastructure for Computing (SNIC) at UPPMAX, partially funded by the Swedish Research Council through grant agreement no. 2018-05973BS. We would also like to thank Marc Friedlander and Emilio Sanchez for advice on data analysis.