Side effects
The self-developed side effect burden questionnaire is based on the Lareb Intensive Monitoring (LIM) system and consists of two parts. In part one patients are asked if they experience side effects that they relate to DOAC use and secondly if they recognize 8 typical side effects attributed to DOAC use. In part two the side effect burden for every reported side effect was rated on a 5-point Likert Scale from 0 (no burden) to 5 (very high burden). A low side effect burden is defined as either no or only minor burdensome side effects, whereas high burden is defined as moderate to very burdensome side effects. Both the percentage of patients reporting side effects as the sum side effect burden per patient are calculated. The side effect burden questionnaire measures the experiential aspect of side effects whereas BMQ question 11 measures the cognitive aspect of side effects.