Abstract
Objective : Severe fever with thrombocytopenia syndrome (SFTS)
and hemorrhagic fever with renal syndrome (HFRS) usually have different
infection routes, and coinfection is relatively rare. The clinical and
etiological characteristics of coinfection by the two pathogens will
provide important references for clinical diagnosis and treatment.
Methods : Blood samples and epidemiological data on HFRS
patients were collected and classified into severe and non-severe groups
according to clinical severity. The differences in clinical
characteristics and levels of pathogens were evaluated and compared.
Results :
A
total of 22 HFRS patient cases were collected from December 2021 to
October 2022. Of these patients, 16 were non-severe and 6 severe.
Patients with rodent exposure history, muscle and joint pain, weight
loss, pharyngeal and conjunctival hyperemia, and positive urine protein
and antibody IGM had a high severe rate (P< 0.05). Molecular
tests on blood samples showed that 3 of the 6 severe patients were
positive for hantavirus, 2 of the 3 hantavirus positives were positive
for bunyavirus.
Conclusion : Severe HFRS patients have different
epidemiological, clinical, and laboratory characteristics. The
coinfection of hantavirus and bunyavirus leads to severe HFRS. These
findings have implications and references for diagnosis and treatment of
coinfected severe cases.
Key Words:Hemorrhagic
fever with renal syndrome (HFRS); Severe fever with thrombocytopenia
syndrome (SFTS); Hantaan orthohantavirus (HTNV); Severe fever with
thrombocytopenia syndrome bunyavirus (SFTSV); Rodent; Tick; Co-infection