Methods
Cyclotron-produced [11C]CO2 was bubbled directly from the target into a solution of BEMP (2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine) and benzylamine.3 Phosphorus(V) oxychloride (POCl3) subsequently reacted for 2 minutes at 0°C to produce the corresponding [11C]isocyanate3 which was then reduced using an excess of sodium borohydride for 10 minutes at 0 °C, yielding the [carbonyl-11C]formamide derivative.
Results and Conclusion