Traditional Medicine Combination Therapy Is A Promising Strategy for
MRSA Infection
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a superbug that
often causes serious inflammation-related injuries. Host immune defense
against MRSA infection and MRSA immune evasion strategies are the main
mechanisms of these injuries. Conventional drugs, such as antibiotics,
optimized antibiotics and vaccines, can treat MRSA infections, but their
use is limited because of drug-resistance and impairment of immunity.
Traditional medicine (TM) therapies, presently used to address these
unmet clinical needs and treat injuries, are regarded as a potential
solution to combat MRSA infection. This review systematically summarizes
the immune mechanisms of MRSA infection, analyzes the efficacy
characteristics and corresponding mechanisms of conventional and TM
therapies in treating injuries, and discusses the potential advantages
of combined therapy. Furthermore, several appropriate immune
responses-related conditions that could be treated with the combination
therapy were summarized, and new perspectives on the clinical and basic
research on this combination therapy were proposed. This review lays a
foundation for the development of anti-MRSA therapies and provides novel
strategies and methods for the treatment of inflammation-related
injuries caused by multiple drug-resistant bacteria.